About Dr. Louis Cai

Dr. Cai is a Board-Certified Ophthalmologist with specialty training in vitreoretinal surgery. He graduated summa cum laude from a combined BS/MD program at the University of Miami.
He completed his ophthalmology residency at the esteemed Wills Eye Hospital in Philadelphia. He received specialty training in vitreoretinal surgery at Bascom Palmer Institute in Miami, consistently ranked by U.S. News as the number one eye hospital in the country.
He treats medical and surgical retinal conditions including retinal tears, retinal detachments, age related macular degeneration, secondary lens placement, and diabetic retinopathy. He has coauthored over thirty papers and presentations, and has a particular interest in the intersection of artificial intelligence and medicine.
He is the producer and cohost of Straight From the Cutters Mouth, a Retina Podcast (retinapodcast.com), the longest running podcast for vitreoretinal surgeons, and is an active member of the American Academy of Ophthalmology, American Society of Retina Specialists, and the Vit Buckle Society.
Originally from Florida, Dr. Cai is fluent in English and proficient in Spanish and Mandarin Chinese. Outside of clinic, he is the cofounder of Cosign AI, a digital health startup, and enjoys spending time outdoors with his wife and two kids.
Hospital Affiliations
- Good Samaritan Hospital
- Los Gatos Surgery Center
- Advanced Surgery Center
Selected Publications
Dr. Cai has contributed to peer-reviewed research in retinal disease, surgical outcomes, and artificial intelligence in ophthalmology.
- Performance of Generative Large Language Models on Ophthalmology Board–Style Questions
LZ Cai, A Shaheen, A Jin, R Fukui, SY Jonathan, N Yannuzzi, C Alabiad
American Journal of Ophthalmology, 2023 - Punctuated Evolution of Canonical Genomic Aberrations in Uveal Melanoma
MG Field, MA Durante, H Anbunathan, LZ Cai, CL Decatur, AM Bowcock, et al.
Nature Communications, 2018 - Applications of Multimodal Generative AI in a Real-World Retina Clinic Setting
S Ghalibafan, DJT Gonzalez, LZ Cai, BG Chou, S Panneerselvam, et al.
Retina, 2022 - Artificial Intelligence in the Management of Diabetic Macular Edema
L Cai, A Jin, JW Hinkle, D Xu, AE Kuriyan
Diabetic Macular Edema (Book Chapter), 2023 - Applications of Artificial Intelligence for the Diagnosis, Prognosis, and Treatment of Age-Related Macular Degeneration
L Cai, JW Hinkle, D Arias, RJ Gorniak, PC Lakhani, AE Flanders, et al.
International Ophthalmology Clinics, 2020 - PRO Score: Predictive Scoring System for Visual Outcomes After Retinal Detachment Repair
LZ Cai, J Lin, MR Starr, A Obeid, EH Ryan, C Ryan, NJ Forbes, D Arias, et al.
British Journal of Ophthalmology, 2023 - Gene Expression Profiling and PRAME Status Versus Tumor-Node-Metastasis Staging for Prognostication in Uveal Melanoma
L Cai, M Paez-Escamilla, SD Walter, B Tarlan, CL Decatur, BM Perez, et al.
American Journal of Ophthalmology, 2018 - See full profile